Specialized membrane domains are an important feature of almost all cells. In particular,
they are essential to tissues that have a highly organized cell cortex, such as the intestinal …

As obligatory intracellular parasites, viruses rely on host-cell functions for most aspects of
their replication cycle. This is born out during entry, when most viruses that infect vertebrate …

The highly related ERM (Ezrin, Radixin, Moesin) proteins provide a regulated linkage
between the membrane and the underlying actin cytoskeleton. They also provide a platform …

There is a growing appreciation that the direct interaction between bacteriophages and the
mammalian host can facilitate diverse and unexplored symbioses. Yet the impact these …

Ezrin is one of the members of the ezrin/radixin/moesin (ERM) family of proteins. It was
originally discovered as an actin-binding protein in the microvilli structure about forty years …

Abstract Ezrin/radixin/moesin (ERM) proteins function as general cross-linkers between
plasma membrane proteins and the actin cytoskeleton and are involved in the functional …

The human Lkb1 kinase, encoded by the ortholog of the invertebrate Par4 polarity gene, is
mutated in Peutz-Jeghers cancer syndrome. Lkb1 activity requires complex formation with …

Using gene expression data to enhance our knowledge of control networks relevant to
cancer biology and therapy is a challenging but urgent task. Based on the premise that …

Rho GTPases are well known regulators of the actin cytoskeleton that act by binding and
activating actin nucleators. They are therefore involved in many actin-based processes …

Abstract Background Dendritic cells (DCs) are important mediators of innate and adaptive
immune responses, but the gene networks governing their lineage differentiation and …