Macrocyclic structures are common synthetic targets in drug discovery,(1, 2) and therefore,
interest in their study is continuously increasing in this field.(3, 4) A classic example is …

Covering 2000 to June 2015 This review discusses the biosynthesis of natural products that
are generated by trans-AT polyketide synthases, a family of catalytically versatile enzymes …

Amines are present in a large majority of drugs and drug candidates. Consequently, the
asymmetric synthesis of amine containing compounds represents an extremely important …

Abstract The Pd-or Ni-catalyzed cross-coupling reactions of organometals containing Zn, Al,
Zr, and B as well as related reactions of Mg and several other metals collectively represent …

Allylic boron compounds have gained a prominent position as a useful class of synthetic
reagents in the past 25 years. Their general structures, 1 and 2, and their utility in carbonyl …

As synthetic targets have grown more complex, protection/deprotection protocols have
assumed prominent roles in synthetic organic chemistry. 1–3 The ability to efficiently protect …

The Burkholderia genus consists of over 40 Gram-negative, beta-proteobacteria species that
occupy remarkably diverse ecological niches. This genus contains species pathogenic to …

The potent antimitotic polyketide macrolide rhizoxin, the causal agent of rice seedling blight,
is not produced by the fungus Rhizopus microsporus, as has been believed for over two …

Molecular rearrangements consisting of base-or acid-induced dislocation of aromatic or
heteroaromaticrings are reviewed. The emphasis is given to recent developments and, in …

Bacteria belonging to the genus Burkholderia live in various ecological niches and present a
significant role in the environments through the excretion of a wide variety of secondary …