Inflammasomes are inflammatory signaling complexes that provide molecular platforms to
activate the protease function of inflammatory caspases. Caspases-1,-4,-5, and-11 are …

Innate immune cells, epithelial cells, and many other cell types are capable of detecting
infection or tissue injury, thus mounting regulated immune response. Inflammasomes are …

Caspase 8 is an initiator caspase that is activated by death receptors to initiate the extrinsic
pathway of apoptosis. Caspase 8 activation involves dimerization and subsequent …

Caspase-11 is a cytosolic sensor and protease that drives innate immune responses to the
bacterial cell wall component, LPS. Caspase-11 provides defence against cytosolic Gram …

Alzheimer's disease (AD) affects people worldwide and is caused by chronic and
progressive damage to the central nervous system. Lycium barbarum (LB), a renowned …

Cordycepin, a major compound separated from Cordyceps sinensis, is known as a potential
novel candidate for cancer therapy. Breast cancer, the most typical cancer diagnosed …

Inflammasomes are multiprotein complexes that coordinate cellular inflammatory responses
and mediate host defense. Following recognition of pathogens and danger signals …

Studying the interactions between a protease and its protein substrates at a molecular level
is crucial for identifying the factors facilitating selection of particular proteolytic substrates …

Caspase-2, a highly conserved member of the caspase family, is considered an initiator
caspase that triggers apoptosis in response to some cellular stresses. Previous studies …

Apoptosis can be routinely characterized using biomolecular markers such as in the TUNEL
and the annexin V assays or by using fluorescent caspase substrates. Apoptosis can also be …