Therapy-related cancers, defined as second primary cancers that arise as a consequence of
chemotherapy and/or radiotherapy, are unusual in that they have a well-defined aetiology …

Non-random chromosomal translocations are frequently associated with a variety of
cancers, particularly hematologic malignancies and childhood sarcomas. In addition to their …

Breakpoint junctions of the chromosomal translocations that occur in human cancers display
hallmarks of nonhomologous end-joining (NHEJ). In mouse cells, translocations are …

Chromosomal rearrangements of the human MLL gene are associated with high-risk
pediatric, adult and therapy-associated acute leukemias. These patients need to be …

Anticancer topoisomerase “poisons” exploit the break-and-rejoining mechanism of
topoisomerase II (TOP2) to generate TOP2-linked DNA double-strand breaks (DSBs). This …

Chromosomal rearrangements of the human MLL gene are a hallmark for aggressive (high-
risk) pediatric, adult and therapy-associated acute leukemias. These patients need to be …

Acute lymphoblastic leukemia (ALL) in infants younger than 1 year is a rare but relatively
homogeneous disease (∼ 80% MLL gene rearranged,∼ 70% CD10-negative) when …

Recurring chromosome abnormalities are strongly associated with certain subtypes of
leukemia, lymphoma and sarcomas. More recently, their potential involvement in …

Approximately 50 different chromosomal translocations of the human MLL gene are
currently known and associated with high-risk acute leukemia. The large number of different …

Type II DNA topoisomerases have the ability to generate a transient DNA double-strand
break through which a second duplex can be passed; an activity essential for DNA …