Persistent SARS-CoV-2 infection, EBV, HHV-6 and other factors may contribute to inflammation and autoimmunity in long COVID

A Vojdani, E Vojdani, E Saidara, M Maes - Viruses, 2023 - mdpi.com
A novel syndrome called long-haul COVID or long COVID is increasingly recognized in a
significant percentage of individuals within a few months after infection with SARS-CoV-2 …

Role of viruses in the pathogenesis of multiple sclerosis

RE Tarlinton, E Martynova, AA Rizvanov… - Viruses, 2020 - mdpi.com
Multiple sclerosis (MS) is an immune inflammatory disease, where the underlying etiological
cause remains elusive. Multiple triggering factors have been suggested, including …

Modulation of intestinal microbiota by the probiotic VSL# 3 resets brain gene expression and ameliorates the age-related deficit in LTP

E Distrutti, JA O'Reilly, C McDonald, S Cipriani… - PloS one, 2014 - journals.plos.org
The intestinal microbiota is increasingly recognized as a complex signaling network that
impacts on many systems beyond the enteric system modulating, among others, cognitive …

Human herpesviruses 6A and 6B in brain diseases: association versus causation

AL Komaroff, PE Pellett, S Jacobson - Clinical microbiology …, 2020 - Am Soc Microbiol
SUMMARY Human herpesvirus 6A (HHV-6A) and human herpesvirus 6B (HHV-6B),
collectively termed HHV-6A/B, are neurotropic viruses that permanently infect most humans …

Role of pathogens in multiple sclerosis

JE Libbey, MF Cusick, RS Fujinami - International reviews of …, 2014 - Taylor & Francis
Multiple sclerosis (MS) is an inflammatory demyelinating autoimmune disease of the central
nervous system (CNS). Although the etiology of MS is unknown, genetic and environmental …

Human herpesvirus 6A and axonal injury before the clinical onset of multiple sclerosis

V Grut, M Biström, J Salzer, P Stridh, D Jons… - Brain, 2024 - academic.oup.com
Recent research indicates that multiple sclerosis is preceded by a prodromal phase with
elevated levels of serum neurofilament light chain (sNfL), a marker of axonal injury. The …

Evidence linking HHV-6 with multiple sclerosis: an update

EC Leibovitch, S Jacobson - Current opinion in virology, 2014 - Elsevier
Highlights•Additional observations of HHV6-specific B and T cell reactivity in MS
CSF.•Evidence of correlations between HHV6 status, polymorphisms and response to …

Genetic, environmental and lifestyle determinants of accelerated telomere attrition as contributors to risk and severity of multiple sclerosis

M Hecker, J Bühring, B Fitzner, PS Rommer, UK Zettl - Biomolecules, 2021 - mdpi.com
Telomeres are protective structures at the ends of linear chromosomes. Shortened telomere
lengths (TL) are an indicator of premature biological aging and have been associated with a …

The presence of human herpesvirus 6 in the brain in health and disease

G Santpere, M Telford, P Andrés-Benito, A Navarro… - Biomolecules, 2020 - mdpi.com
The human herpesvirus 6 (HHV-6)-A and-B are two dsDNA beta-herpesviruses infecting
almost the entire worldwide population. These viruses have been implicated in multiple …

The role of microorganisms in the etiopathogenesis of demyelinating diseases

J Frau, G Coghe, L Lorefice, G Fenu, E Cocco - Life, 2023 - mdpi.com
Multiple sclerosis (MS), neuromyelitis optica (NMO) and myelin oligodendrocyte
glycoprotein antibody disease (MOGAD) are inflammatory diseases of the central nervous …