Proprotein convertase subtilisin/kexin type 9 (PCSK9) has evolved as a pivotal enzyme in
lipid metabolism and a revolutionary therapeutic target for hypercholesterolemia and its …

Background Cancer is emerging as a major problem globally, as it accounts for the second
cause of death despite medical advances. According to epidemiological and basic studies …

Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) is the ninth member of
the proprotein convertase family that regulates lipoprotein homeostasis and altered PCSK9 …

Background Prostate cancer (PrCa) is the second most prevalent malignancy in men
worldwide. Observational studies have linked the use of low-density lipoprotein cholesterol …

When secreted into the circulation, proprotein convertase subtilisin kexin type 9 (PCSK9)
blocks the low-density lipoprotein receptors (LDL-R) and, as a consequence, low-density …

Proprotein convertase subtilisin/kexin type 9 (PCSK9) has emerged as a novel
pharmacological target for hypercholesterolemia and associated cardiovascular diseases …

The tumor microenvironment is a complex space comprised of normal, cancer and immune
cells. The macrophages are considered as the most abundant immune cells in tumor …

Background Disturbance of cholesterol homeostasis is considered as one of the
manifestations of cancer. Cholesterol plays an essential role in the pleiotropic functions of …

Breast cancer is one of the most common malignancies in women and the leading cause of
cancer mortality. Hypercholesterolemia and obesity are potential risk factors for the …

Cancer is a disease with a significant global burden in terms of premature mortality, loss of
productivity, healthcare expenditures, and impact on mental health. Recent decades have …