Immunotherapy is a clinically validated treatment for many cancers to boost the immune
system against tumor growth and dissemination. Several strategies are used to harness …

Chemokines are a large family of small chemotactic cytokines that coordinates immune cell
trafficking. In cancer, they have a pivotal role in the migration pattern of immune cells into the …

Purpose Adult T-cell leukemia-lymphoma (ATL) is a distinct mature T-cell malignancy
caused by chronic infection with human T-lymphotropic virus type 1 with diverse clinical …

Adult T-cell leukemia/lymphoma (ATL) is a highly aggressive T-cell malignancy that arises in
a proportion of individuals who are long-term carriers of human T-lymphotropic virus type 1 …

Simple Summary CCR4 is a chemokine receptor selectively expressed on normal T cell
subsets such as type 2 helper T cells, skin-homing T cells and regulatory T cells, and on skin …

Introduction: Despite improvements in human leukocyte antigen (HLA) matching algorithms
and supportive care, graft-versus-host disease (GVHD) remains the leading cause of non …

Chemokines are a large subfamily of cytokines known for their ability to facilitate cell
migration, most notably leukocytes, throughout the body. Chemokines are necessary for a …

Cutaneous T-cell lymphoma (CTCL) is a heterogeneous disease group of unknown etiology
with a complex immunological background. As CTCL arises from T cells that have a vital role …

During the past 40 years, cytokines and chemokines have been extensively investigated as
either cancer targets or cancer treatments. A strong preclinical rationale supports therapeutic …

ATL: adult T-cell leukemia-lymphoma; ATL-PI: ATL-prognostic index; mLSG15: vincristine
(VCR), cyclophosphamide (CY), doxorubicin (DOX) and prednisone (PSL), DOX …