Nigella sativa, a plant widely used in traditional medicine, possesses anti-inflammatory,
antioxidant and neuroprotective properties. In the present study, we investigated the effect of …

Nicorandil (NIC) is a well-known anti-anginal agent, which has been recommended as one
of the second-line treatments for chronic stable angina as justified by the European …

Objective Currently, most models of vascular cognitive impairment are established by
occluding the carotid arteries uni-or bilaterally to reduce the cerebral blood flow mimicking …

Nicorandil is a dual mechanism anti-anginal agent that acts as a nitric oxide (NO) donor and
a potassium (K+) channel opener. Recent studies have evaluated the effect of nicorandil on …

Multiple sclerosis (MS) is an inflammatory demyelinating neurodegenerative disease that
negatively affects neurotransmission. It can be pathologically mimicked by experimental …

Dengzhan Shengmai (DZSM) is a proprietary Chinese medicine for remarkable curative
effect as a treatment of cerebrovascular diseases, such as chronic cerebral hypoperfusion …

Panax ginseng is a slow-growing perennial plant. Panax ginseng extract has numerous
biological activities, including antitumor, anti-inflammatory and antistress activities. Panax …

With population growth and aging, more and more patients with cerebral infarction have
varying degrees of disability. ATP-sensitive potassium (KATP) channels regulate many …

Mutations in the human granulin (GRN) gene are associated with multiple diseases,
including dementia disorders such as frontotemporal dementia (FTD) and limbic …

Glucose-responsive ATP-sensitive potassium channels (K ATP) are expressed in a variety of
tissues including nervous systems. The depolarization of the membrane potential induced …