The heart is the most metabolically flexible organ with respect to the use of substrates
available in different states of energy metabolism. Cardiac mitochondria sense substrate …

Foamy macrophages, which have prominent lipid droplets (LDs), are found in a variety of
disease states. Toll-like receptor agonists drive triacylglycerol (TG)-rich LD development in …

Reducing infarct size during a cardiac ischaemic‐reperfusion episode is still of paramount
importance, because the extension of myocardial necrosis is an important risk factor for …

Pharmacological conditioning aims to protect the heart from myocardial ischemia-
reperfusion injury (IRI). Despite extensive research in this area, today, a significant gap …

Carnitine plays essential roles in intermediary metabolism. In non-vegetarians, most of
carnitine sources (~ 75%) are obtained from diet whereas endogenous synthesis accounts …

Obesity‐induced insulin resistance and type 2 diabetes mellitus can ultimately result in
various complications, including diabetic cardiomyopathy. In this case, cardiac dysfunction is …

Ischemic heart disease refers to myocardial degeneration, necrosis, and fibrosis caused by
coronary artery disease. It can lead to severe left ventricular dysfunction (LVEF≤ 35–40%) …

Rationale: The mTORC1 (mechanistic target of rapamycin complex-1) controls metabolism
and protein homeostasis and is activated following ischemia reperfusion (IR) injury and by …

Prochloraz (PCZ), an imidazole fungicide, has been extensively used in horticulture and
agriculture to protect against pests and diseases. To investigate the potential toxicity of PCZ …

Cardiac metabolism is a high-oxygen-consuming process, showing a preference for long-
chain fatty acid (LCFA) as the fuel source under physiological conditions. However, a …