[HTML][HTML] Histone ubiquitination: an integrative signaling platform in genome stability
F Mattiroli, L Penengo - Trends in Genetics, 2021 - cell.com
Complex mechanisms are in place to maintain genome stability. Ubiquitination of chromatin
plays a central role in these mechanisms. The ever-growing complexity of the ubiquitin (Ub) …
plays a central role in these mechanisms. The ever-growing complexity of the ubiquitin (Ub) …
Sumoylation on its 25th anniversary: mechanisms, pathology, and emerging concepts
Sumoylation is an essential post‐translational modification intimately involved in a diverse
range of eukaryotic cellular mechanisms. Small ubiquitin‐like modifier (SUMO) protein …
range of eukaryotic cellular mechanisms. Small ubiquitin‐like modifier (SUMO) protein …
Histone sumoylation and chromatin dynamics
HY Ryu, M Hochstrasser - Nucleic Acids Research, 2021 - academic.oup.com
Chromatin structure and gene expression are dynamically controlled by post-translational
modifications (PTMs) on histone proteins, including ubiquitylation, methylation, acetylation …
modifications (PTMs) on histone proteins, including ubiquitylation, methylation, acetylation …
Functional role of G9a histone methyltransferase in cancer
Post-translational modifications of DNA and histones are epigenetic mechanisms, which
affect the chromatin structure, ultimately leading to gene expression changes. A number of …
affect the chromatin structure, ultimately leading to gene expression changes. A number of …
The solid and liquid states of chromatin
The review begins with a concise description of the principles of phase separation. This is
followed by a comprehensive section on phase separation of chromatin, in which we recount …
followed by a comprehensive section on phase separation of chromatin, in which we recount …
Nucleosomal arrays self‐assemble into supramolecular globular structures lacking 30‐nm fibers
The existence of a 30‐nm fiber as a basic folding unit for DNA packaging has remained a
topic of active discussion. Here, we characterize the supramolecular structures formed by …
topic of active discussion. Here, we characterize the supramolecular structures formed by …
[HTML][HTML] Epigenetic regulation of astrocyte function in neuroinflammation and neurodegeneration
M Neal, JR Richardson - Biochimica et Biophysica Acta (BBA)-Molecular …, 2018 - Elsevier
Epigenetic mechanisms control various functions throughout the body, from cell fate
determination in development to immune responses and inflammation. Neuroinflammation …
determination in development to immune responses and inflammation. Neuroinflammation …
BRCA1/BARD1 site-specific ubiquitylation of nucleosomal H2A is directed by BARD1
Mutations in the E3 ubiquitin ligase RING domains of BRCA1/BARD1 predispose carriers to
breast and ovarian cancers. We present the structure of the BRCA1/BARD1 RING …
breast and ovarian cancers. We present the structure of the BRCA1/BARD1 RING …
Chromatin regulation through ubiquitin and ubiquitin-like histone modifications
Chromatin functions are influenced by the addition, removal, and recognition of histone post-
translational modifications (PTMs). Ubiquitin and ubiquitin-like (UBL) PTMs on histone …
translational modifications (PTMs). Ubiquitin and ubiquitin-like (UBL) PTMs on histone …
SUMO interacting motifs: structure and function
TY Yau, W Sander, C Eidson, AJ Courey - Cells, 2021 - mdpi.com
Small ubiquitin-related modifier (SUMO) is a member of the ubiquitin-related protein family.
SUMO modulates protein function through covalent conjugation to lysine residues in a large …
SUMO modulates protein function through covalent conjugation to lysine residues in a large …