The development of synthetic methods for the introduction of the fluorine atom and
fluoroalklyl groups into organic molecules has gained increased attention. Synthetic organic …

Halodifluoromethyl and trifluoromethyl-containing compounds are widely employed in
organic chemistry, pharmaceuticals and materials science. Therefore, their applications and …

Conspectus Difluoroalkylated compounds play a remarkably important role in life and
materials sciences because of the unique characteristics of the difluoromethylene (CF2) …

We report the first palladium hydride enabled hydroalkenylation of strained molecules. This
new mild protocol proceeds via a regio-and chemoselective hydropalladation step, followed …

The use of metal catalysts to produce and control the reactivity of carbenes has long offered
a powerful approach to organic synthesis; however, difluorocarbene transfer catalysed by …

Fluoroalkyl groups profoundly affect the physical properties of pharmaceuticals and
influence almost all metrics associated with their pharmacokinetic and pharmacodynamic …

Conspectus Compounds containing a difluoromethylene unit have gained increasing
attention due to their utility in drug design. Classic methods for the synthesis of these …

Cyclopropane skeletons play a prominent role in the development of organic synthesis and
pharmaceutical chemistry. Herein, we report the design and synthesis of a stable …

Fluoroalkylation reaction, featuring the transfer of a fluoroalkyl group to a substrate, is a
straightforward and efficient method for the synthesis of organofluorine compounds. In …

Difluorocarbene has important applications in pharmaceuticals, agrochemicals and
materials, but all these applications proceed using just a few types of reaction by taking …