High-quality chromosome-scale haplotype sequences of diploid genomes, polyploid
genomes, and metagenomes provide important insights into genetic variation associated …

Polyploidy has been observed throughout major eukaryotic clades and has played a vital
role in the evolution of angiosperms. Recent polyploidizations often result in highly complex …

Haplotype-aware diploid genome assembly is crucial in genomics, precision medicine, and
many other disciplines. Long-read sequencing technologies have greatly improved genome …

With viral infections, multiple related viral strains are often present due to coinfection or
within-host evolution. We describe Haploflow, a deBruijn graph-based assembler for de …

Next-generation sequencing–based metagenomics has enabled to identify microorganisms
in characteristic habitats without the need for lengthy cultivation. Importantly, clinically …

Premise Hybridization is recognized as an important mechanism in fern speciation, with
many allopolyploids known among congeners, as well as evidence of ancient genome …

Reconstructing haplotypes from sequencing data is one of the major challenges in genetics.
Haplotypes play a crucial role in many analyses, including genome-wide association studies …

Different strains of identical species can vary substantially in terms of their spectrum of
biomedically relevant phenotypes. Reconstructing the genomes of microbial communities at …

The large amount and diversity of viral genomic datasets generated by next-generation
sequencing technologies poses a set of challenges for computational data analysis …

Motivation The microbes that live in an environment can be identified from the combined
genomic material, also referred to as the metagenome. Sequencing a metagenome can …