The primary cilium is a hair-like surface-exposed organelle of the eukaryotic cell that
decodes a variety of signals—such as odorants, light and Hedgehog morphogens—by …

The primary cilium is an antenna-like cellular protrusion mediating sensory and
neuroendocrine signaling. Its localization within tissue architecture and a growing list of cilia …

Macromolecular protein complexes carry out many of the essential functions of cells, and
many genetic diseases arise from disrupting the functions of such complexes. Currently …

The cilium evolved to provide the ancestral eukaryote with the ability to move and sense its
environment. Acquiring these functions required the compartmentalization of a dynein …

Cilia dysfunction underlies a class of human diseases with variable penetrance in different
organ systems. Across eukaryotes, intraflagellar transport (IFT) facilitates cilia biogenesis …

The transition zone (TZ) ciliary subcompartment is thought to control cilium composition and
signalling by facilitating a protein diffusion barrier at the ciliary base. TZ defects cause …

Cilia have a unique diffusion barrier (“gate”) within their proximal region, termed transition
zone (TZ), that compartmentalises signalling proteins within the organelle. The TZ is known …

Abstract Small GTPases including Ras, Rho, Rab, Arf, and Ran are omnipresent molecular
switches in regulating key cellular functions. Their dysregulation is a therapeutic target for …

The cilium is an essential organelle at the surface of mammalian cells whose dysfunction
causes a wide range of genetic diseases collectively called ciliopathies. The current rate at …

Cilia are microtubule‐based, cell‐surface projections whose machinery is evolutionarily
conserved. In vertebrates, cilia are observed on almost every cell type and are either motile …