Recent advances in applications of droplet microfluidics

WL Chou, PY Lee, CL Yang, WY Huang, YS Lin - Micromachines, 2015 - mdpi.com
Droplet-based microfluidics is a colloidal and interfacial system that has rapidly progressed
in the past decade because of the advantages of low fabrication costs, small sample …

Microfluidic exosome analysis toward liquid biopsy for cancer

M He, Y Zeng - Journal of laboratory automation, 2016 - journals.sagepub.com
Assessment of a tumor's molecular makeup using biofluid samples, known as liquid biopsy,
is a prominent research topic in precision medicine for cancer, due to its noninvasive …

Isothermal nucleic acid amplification based microfluidic “lab-on-a-chip” for the detection of pathogenic bacteria and viruses in agri-foods

Y Lu, J Zhang, X Lu, Q Liu - Trends in Food Science & Technology, 2024 - Elsevier
Background Food safety is a global health issue. The major causes of foodborne diseases,
including bacteria, viruses, parasites, prions, and chemicals in unsafe food, lead to severe …

PillarX: a microfluidic device to profile circulating tumor cell clusters based on geometry, deformability, and epithelial state

BJ Green, M Marazzini, B Hershey, A Fardin, Q Li… - Small, 2022 - Wiley Online Library
Circulating tumor cell (CTC) clusters are associated with increased metastatic potential and
worse patient prognosis, but are rare, difficult to count, and poorly characterized …

A filter-electrochemical microfluidic chip for multiple surface protein analysis of exosomes to detect and classify breast cancer

Y Wang, W Gao, M Sun, B Feng, H Shen, J Zhu… - Biosensors and …, 2023 - Elsevier
Breast cancer (BC) is a complex disease with high variability and no specific tumor markers
available for diagnosis. Exosomes contain rich maternal tumor information and are a novel …

Ultrasensitive Analysis of Exosomes Using a 3D Self-Assembled Nanostructured SiO2 Microfluidic Chip

Q Li, Y Wang, Y Xue, L Qiao, G Yu… - ACS Applied Materials …, 2022 - ACS Publications
Conventional microfluidics with a solid mixer for exosome detection is constrained by the
low binding efficiency of the solid–liquid boundary effects and reduced sensitivity of …

Controlled 3D culture in Matrigel microbeads to analyze clonal acinar development

ME Dolega, F Abeille, N Picollet-d'Hahan, X Gidrol - Biomaterials, 2015 - Elsevier
Abstract 3D culture systems are a valuable tool for modeling morphogenesis and
carcinogenesis of epithelial tissue in a structurally appropriate context. We present a novel …

Ultrasensitive microfluidic solid-phase ELISA using an actuatable microwell-patterned PDMS chip

T Wang, M Zhang, DD Dreher, Y Zeng - Lab on a Chip, 2013 - pubs.rsc.org
Quantitative detection of low abundance proteins is of significant interest for biological and
clinical applications. Here we report an integrated microfluidic solid-phase ELISA platform …

[HTML][HTML] Advances, challenges, and opportunities in extracellular RNA biology: insights from the NIH exRNA Strategic Workshop

K Li, RS Rodosthenous, F Kashanchi, T Gingeras… - JCI insight, 2018 - ncbi.nlm.nih.gov
Extracellular RNA (exRNA) has emerged as an important transducer of intercellular
communication. Advancing exRNA research promises to revolutionize biology and transform …

Hydrogel-driven paper-based microfluidics

RR Niedl, C Beta - Lab on a Chip, 2015 - pubs.rsc.org
Paper-based microfluidics provide an inexpensive, easy to use technology for point-of-care
diagnostics in developing countries. Here, we combine paper-based microfluidic devices …