Akt signaling pathway in macrophage activation and M1/M2 polarization
E Vergadi, E Ieronymaki, K Lyroni… - The Journal of …, 2017 - journals.aai.org
Macrophages become activated initiating innate immune responses. Depending on the
signals, macrophages obtain an array of activation phenotypes, described by the broad …
signals, macrophages obtain an array of activation phenotypes, described by the broad …
[HTML][HTML] Innate immune programing by endotoxin and its pathological consequences
Monocytes and macrophages play pivotal roles in inflammation and homeostasis. Recent
studies suggest that dynamic programing of macrophages and monocytes may give rise to …
studies suggest that dynamic programing of macrophages and monocytes may give rise to …
The target landscape of clinical kinase drugs
INTRODUCTION Molecularly targeted drugs such as imatinib and crizotinib have
revolutionized the treatment of certain blood and lung cancers because of their remarkable …
revolutionized the treatment of certain blood and lung cancers because of their remarkable …
PI3Kγ is a molecular switch that controls immune suppression
MM Kaneda, KS Messer, N Ralainirina, H Li, CJ Leem… - Nature, 2016 - nature.com
Macrophages play critical, but opposite, roles in acute and chronic inflammation and
cancer,,,,. In response to pathogens or injury, inflammatory macrophages express cytokines …
cancer,,,,. In response to pathogens or injury, inflammatory macrophages express cytokines …
Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin
Obesity and resistance to insulin are closely associated with the development of low-grade
inflammation. Interleukin 6 (IL-6) is linked to obesity-associated inflammation; however, its …
inflammation. Interleukin 6 (IL-6) is linked to obesity-associated inflammation; however, its …
Toll-like receptors, signaling adapters and regulation of the pro-inflammatory response by PI3K
TLRs are a family of pattern recognition receptors that recognize conserved molecular
structures/products from a wide variety of microbes. Following recognition of ligands, TLRs …
structures/products from a wide variety of microbes. Following recognition of ligands, TLRs …
[HTML][HTML] Macrophage PTEN regulates expression and secretion of arginase I modulating innate and adaptive immune responses
E Sahin, S Haubenwallner, M Kuttke… - The Journal of …, 2014 - journals.aai.org
The activation of innate immune cells triggers numerous intracellular signaling pathways,
which require tight control to mount an adequate immune response. The PI3K signaling …
which require tight control to mount an adequate immune response. The PI3K signaling …
Molecular mechanisms responsible for the selective and low-grade induction of proinflammatory mediators in murine macrophages by lipopolysaccharide
Low-dose endotoxemia is prevalent in humans with adverse health conditions, and it
correlates with the pathogenesis of chronic inflammatory diseases such as atherosclerosis …
correlates with the pathogenesis of chronic inflammatory diseases such as atherosclerosis …
Therapeutic inhibition of miR-375 attenuates post-myocardial infarction inflammatory response and left ventricular dysfunction via PDK-1-AKT signalling axis
Aims Increased miR-375 levels has been implicated in rodent models of myocardial
infarction (MI) and with patients with heart failure. However, no prior study had established a …
infarction (MI) and with patients with heart failure. However, no prior study had established a …
Negative regulation of TLR signaling in myeloid cells—implications for autoimmune diseases
JA Hamerman, J Pottle, M Ni, Y He… - Immunological …, 2016 - Wiley Online Library
Toll‐like receptors (TLR) are transmembrane pattern recognition receptors that recognize
microbial ligands and signal for production of inflammatory cytokines and type I interferon in …
microbial ligands and signal for production of inflammatory cytokines and type I interferon in …