Pain and neurodevelopmental outcomes of infants born very preterm

V Giordano, P Deindl, E Gal… - … Medicine & Child …, 2023 - Wiley Online Library
Aim To investigate the impact of the level of pain experienced by infants born preterm on
neurodevelopmental outcomes during their stay in a neonatal intensive care unit. Method In …

[HTML][HTML] Long-term effects of neonatal pain and sucrose treatment

K Nuseir, KH Alzoubi, A Altarifi, M Kassab… - Current Research in …, 2024 - Elsevier
Purpose In neonatal intensive care units, applying sucrose solution for analgesia is now a
routine treatment for mild procedural pain. Studies of animal and human infants provide …

Identification of compounds that cause axonal dieback without cytotoxicity in dorsal root ganglia explants and intervertebral disc cells with potential to treat pain via …

FS Lee, UN Nguyen, EJ Munns, RA Wachs - Plos one, 2024 - journals.plos.org
Low back pain, knee osteoarthritis, and cancer patients suffer from chronic pain. Aberrant
nerve growth into intervertebral disc, knee, and tumors, are common pathologies that lead to …

Early life nociceptive stimulus and fentanyl exposure increase hippocampal neurogenesis and anxiety but do not affect spatial learning and memory

DSB Rêgo, CS Silva, LEAM Mello… - Frontiers in …, 2022 - frontiersin.org
This study aimed to determine whether preemptive fentanyl administration in neonatal rats
reduces the impact of a nociceptive stimulus initiated during the first day of life (P1) on …

Current Evidence for Biological Biomarkers and Mechanisms Underlying Acute to Chronic Pain Transition across the Pediatric Age Spectrum

IT Duff, KN Krolick, HM Mahmoud… - Journal of Clinical …, 2023 - mdpi.com
Chronic pain is highly prevalent in the pediatric population. Many factors are involved in the
transition from acute to chronic pain. Currently, there are conceptual models proposed, but …

Effect of combining oral glucose solutions with supportive positions on pain during heel puncture blood sampling in premature infants: A randomized quadruple …

G Ugucu, R Yigit, Y Celik - Journal of Pediatric Nursing, 2024 - Elsevier
Purpose The trial aimed to assess the impact on pain scores of the administration of oral
glucose solutions at different concentrations and in combination with supportive positions …

Long-term Effects of Cannabidiol and/or Fentanyl Exposure in Rats Submitted to Neonatal Pain

DSB Rêgo, ML Calió, R Filev, LE Mello, ATFS Leslie - The Journal of Pain, 2024 - Elsevier
The current study aimed to evaluate anxiety behavior, hippocampal ionized calcium-binding
adaptor molecule 1 (Iba1) and cannabinoid receptor 1 (CB1) gene expression, and …

Long-Term Influences of Neonatal Pain-Related Stress on Cognitive and Stress-Hormonal Functions in Rats: Age and Sex Aspects

IP Butkevich, VA Mikhailenko, EA Vershinina - Journal of Evolutionary …, 2023 - Springer
To address the problem of neonatal pain-related stress effects on spatial learning, memory
and the stress reactivity of the hypothalamo–pituitary–adrenal axis (the HPA) in adolescent …

[HTML][HTML] Improving Procedural Pain Management for Newborns in a Level 3 Neonatal Intensive Care Unit: A Quality Improvement Initiative

S Sriraman, P Chitamanni, RK Yadav, S Ranu - Cureus, 2024 - pmc.ncbi.nlm.nih.gov
Introduction: Neonatal pain has been associated with numerous adverse outcomes, making
pain management essential in the neonatal intensive care unit (NICU). Our specific …

Short-term effects of repeated neonatal oral sucrose treatment and pain on hippocampal and serum inflammatory cytokine levels and microglia density in mouse pups

FS Hoq - 2023 - open.library.ubc.ca
Background: In the neonatal intensive care unit, preterm infants experience 7-17 clinically
required but painful procedures daily. Oral sucrose is the standard treatment for minor …