Aims To appraise the clinical and genetic evidence that low-density lipoproteins (LDLs)
cause atherosclerotic cardiovascular disease (ASCVD). Methods and results We assessed …

People who maintain ideal cardiovascular heath have a low lifetime risk of cardiovascular
disease. Therefore, encouraging people to achieve ideal cardiovascular health represents …

We report a genome-wide association study (GWAS) of coronary artery disease (CAD)
incorporating nearly a quarter of a million cases, in which existing studies are integrated with …

Abstract The Million Veteran Program (MVP) was established in 2011 as a national research
initiative to determine how genetic variation influences the health of US military veterans …

Importance Triglycerides and cholesterol are both carried in plasma by apolipoprotein B
(ApoB)–containing lipoprotein particles. It is unknown whether lowering plasma triglyceride …

Abstract Mendelian randomization-Egger (MR-Egger) is an analysis method for Mendelian
randomization using summarized genetic data. MR-Egger consists of three parts:(1) a test …

Results from genome-wide association studies (GWAS) can be used to infer causal
relationships between phenotypes, using a strategy known as 2-sample Mendelian …

Health risk factors such as body mass index (BMI) and serum cholesterol are associated
with many common diseases. It often remains unclear whether the risk factors are cause or …

Mendelian randomization (MR) is an epidemiological technique that uses genetic variants to
distinguish correlation from causation in observational data. The reliability of a MR …

Mendelian randomization (MR) uses genetic data to probe questions of causality in
epidemiological research, by invoking the Instrumental Variable (IV) assumptions. In recent …