Beyond their role in hemostasis and thrombosis, platelets are increasingly recognized as
key regulators of the inflammatory response under sterile and infectious conditions. Both …

The immunoglobulin receptor GPVI (glycoprotein VI) is selectively expressed on
megakaryocytes and platelets and is currently recognized as a receptor for not only collagen …

It has previously been shown in several animal experiments that platelet GPVI (glycoprotein
VI) contributes to thrombosis, particularly in ischemic stroke. Moreover, GPVI levels are …

Platelets are key vascular effectors in hemostasis, with activation signals leading to fast
recruitment, aggregation, and clot formation. The canonical process of hemostasis is well …

New findings highlight the complex interplay of innate immunity, coagulation and platelets in
inflammation and infection, and unravel novel molecular pathways and effector functions …

Microscopy imaging has enabled us to establish the presence of fibrin (ogen) amyloid
(fibrinaloid) microclots in a range of chronic, inflammatory diseases. Microclots may also be …

Much interest surrounds the receptors α2β1 and glycoprotein VI (GPVI) whose synchronized
action mediates the attachment and activation of platelets on collagen, essential for …

Diabetic wound healing (DWH) represents a major complication of diabetes where
inflammation is a key impediment to proper healing. The cyclic GMP-AMP synthase (cGAS) …

Type 2 diabetes mellitus (T2DM) is a multifactorial disease with a dysregulated circulating
inflammatory molecule tendency. T2DM is closely associated with systemic inflammation …

Platelets play a key role in the development, progression and resolution of the inflammatory
response during sterile inflammation and infection, although the mechanism is not well …