MicroRNAs (miRNAs) are essential post-transcriptional gene regulators involved in various
neuronal and non-neuronal cell functions and play a key role in pathological conditions …

The change from viewing noncoding RNA as “junk” in the genome to seeing it as a critical
epigenetic regulator in almost every human condition or disease has forced a paradigm shift …

Deregulation of RNA metabolism has emerged as one of the key events leading to the
degeneration of motor neurons (MNs) in Amyotrophic Lateral Sclerosis (ALS) disease …

RNA metabolism is central to cellular physiopathology. Almost all the molecular pathways
underpinning biological processes are affected by the events governing the RNA life cycle …

Objective Neurofilament light chain (NfL) is a promising biomarker in genetic frontotemporal
dementia (FTD) and amyotrophic lateral sclerosis (ALS). We evaluated plasma …

Background: Alzheimer's disease (AD) patients are often accompanied by depressive
symptoms, but its underlying mechanism remains unclear. The present study aimed to …

Frontotemporal dementia (FTD) is one of the most common neurodegenerative diseases,
encompassing a myriad of different, clinically distinct subtypes which all target the …

Background Amyotrophic lateral sclerosis (ALS) is a progressive, fatal neurodegenerative
disorder (NDS) with unclear pathophysiology and few therapeutic options. Mutations in …

Introduction Development and worsening of most common neurodegenerative diseases,
such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis, have been …

Frontotemporal lobar degeneration describes a group of progressive brain disorders that
primarily are associated with atrophy of the prefrontal and anterior temporal lobes …