The uptake of calcium into and extrusion of calcium from the mitochondrial matrix is a fundamental biological process that has critical effects on cellular metabolism, signaling …
KB Wallace, VA Sardão, PJ Oliveira - Circulation research, 2020 - Am Heart Assoc
Anthracycline-based chemotherapy can result in the development of a cumulative and progressively developing cardiomyopathy. Doxorubicin is one of the most highly prescribed …
Although the development of mitochondrial therapies has largely focused on diseases caused by mutations in mitochondrial DNA or in nuclear genes encoding mitochondrial …
EO Mikhailova - Journal of Functional Biomaterials, 2021 - mdpi.com
Gold nanoparticles (AuNPs) are extremely promising objects for solving a wide range of biomedical problems. The gold nanoparticles production by biological method (“green …
A De Gaetano, K Solodka, G Zanini, V Selleri… - Cells, 2021 - mdpi.com
Besides their role in cell metabolism, mitochondria display many other functions. Mitochondrial DNA (mtDNA), the own genome of the organelle, plays an important role in …
B Gan - Journal of Cell Biology, 2021 - rupress.org
Ferroptosis is a form of iron-dependent regulated cell death driven by uncontrolled lipid peroxidation. Mitochondria are double-membrane organelles that have essential roles in …
EM Wenzel, LA Elfmark, H Stenmark… - Journal of cell biology, 2022 - rupress.org
The endoplasmic reticulum (ER), which occupies a large portion of the cytoplasm, is the cell's main site for the biosynthesis of lipids and carbohydrate conjugates, and it is essential …
S Baliou, M Adamaki, P Ioannou… - Molecular …, 2021 - build.spandidos-publications.com
Taurine is a fundamental mediator of homeostasis that exerts multiple roles to confer protection against oxidant stress. The development of hypertension, muscle/neuro‑ …
E Bertero, C Maack - Circulation research, 2018 - Am Heart Assoc
In heart failure, alterations of Na+ and Ca2+ handling, energetic deficit, and oxidative stress in cardiac myocytes are important pathophysiological hallmarks. Mitochondria are central to …