Airway epithelial barrier dysfunction is frequently observed in asthma and may have
important implications. The physical barrier function of the airway epithelium is tightly …

Asthma is a global health problem with increasing prevalence. The airway epithelium is the
initial barrier against inhaled noxious agents or aeroallergens. In asthma, the airway …

An emerging paradigm proposes a crucial role for lung resident mesenchymal stem cells
(LR-MSCs) via a fibroblastic transdifferentiation event in the pathogenesis of idiopathic …

Current limitations to primary cell expansion led us to test whether airway epithelial cells
derived from healthy children and those with asthma and cystic fibrosis (CF), co-cultured …

Chronic obstructive pulmonary disease (COPD) and lung cancer are major lung diseases
affecting millions worldwide. Both diseases have links to cigarette smoking and exert a …

Introduction: COPD and lung cancer are leading causes of morbidity and mortality
worldwide, and they share a common environmental risk factor in cigarette smoke exposure …

The in vitro-directed differentiation of pluripotent stem cells (PSCs) through stimulation of
developmental signaling pathways can generate mature somatic cell types for basic …

Breast cancer is one of the most common malignancies in women. Patient-derived tumor
xenograft (PDX) model is a cutting-edge approach for drug research on breast cancer …

In asthma, goblet cell numbers are increased within the airway epithelium, perpetuating the
production of mucus that is more difficult to clear and results in airway mucus plugging …

The 'language'of covalent histone modifications translates environmental and cellular cues
into gene expression. This vast array of post-translational modifications on histones are …