Feeding, which is essential for all animals, is regulated by homeostatic mechanisms. In
addition, food consumption is temporally coordinated by the brain over the circadian (~ 24 h) …

The initial discovery that ob/ob mice become obese because of a recessive mutation of the
leptin gene has been crucial to discover the melanocortin pathway to control appetite. In the …

With our aging society, more people hope for a long and healthy life. In recent years,
researchers have focused on healthy longevity factors. In particular, calorie restriction delays …

Abstract Melanocortin-3 and 4 receptors (MC3R and MC4R) can regulate energy
homeostasis, but their respective roles especially the functions of MC3R need more …

Anorexia nervosa (AN) is a debilitating eating disorder characterized by severely restricted
eating and significant body weight loss. In addition, many individuals also report engaging in …

The obesity epidemic is a major health and economic burden facing both developed and
developing countries worldwide. Interrogation of the central and peripheral mechanisms …

Melanocortin neurons conserve body mass in hyper-or hypo-caloric conditions by conveying
signals from nutrient sensors into areas of the brain governing appetite and metabolism. In …

Understanding the complex action mechanism of appetite regulation peptides can
significantly impact therapeutic options in the treatment of obesity and other metabolic …

Growth hormone secretagogue receptor 1a (GHS-R1a) is an important G protein-coupled
receptor (GPCR) that regulates a variety of functions by binding to ghrelin. It has been …

Objective Appetitive responses to weight loss are mediated by a nutrient-sensing neural
network comprised of melanocortin neurons. The role of neural melanocortin-3 receptors …