Nanomaterials in tumor immunotherapy: new strategies and challenges

X Zhu, S Li - Molecular Cancer, 2023 - Springer
Tumor immunotherapy exerts its anti-tumor effects by stimulating and enhancing immune
responses of the body. It has become another important modality of anti-tumor therapy with …

Development and application of nanomaterials, nanotechnology and nanomedicine for treating hematological malignancies

J Li, Q Wang, Y Han, L Jiang, S Lu, B Wang… - Journal of Hematology & …, 2023 - Springer
Hematologic malignancies (HMs) pose a serious threat to patients' health and life, and the
five-year overall survival of HMs remains low. The lack of understanding of the pathogenesis …

[HTML][HTML] Synergistic therapeutic antitumor effect of PD-1 blockade cellular vesicles in combination with Iguratimod and Rhodium nanoparticles

M Younis, Y Wu, Q Fang, H Shan, X Huang - Journal of Colloid and …, 2023 - Elsevier
Immune checkpoint blockade has emerged as a significant therapeutic development in
immunotherapy during the past decade. However, only a small percentage of cancer …

Highly Efficient Oral Iguratimod/Polyvinyl Alcohol Nanodrugs Fabricated by High‐Gravity Nanoprecipitation Technique for Treatment of Rheumatoid Arthritis

C Tao, F Li, Z Ma, X Li, Y Zhang, Y Le, J Wang, J Zhao… - Small, 2024 - Wiley Online Library
Rheumatoid arthritis (RA), a systemic autoimmune disease, poses a significant human
health threat. Iguratimod (IGUR), a novel disease‐modifying antirheumatic drug (DMARD) …

Effects of iguratimod on inflammatory factors and apoptosis of submandibular gland epithelial cells in NOD mice

S Wang, J Yu, J Yang, Y Ge, J Tian - Scientific Reports, 2023 - nature.com
Non-obese diabetic (NOD) mice were taken as primary Sjögren's syndrome (pSS) model
mice to examine the therapeutic impact of iguratimod (IGU) on inflammatory factors levels …

Targeted Delivery Strategies for Multiple Myeloma and Their Adverse Drug Reactions

S Li, H Wang, S Xiong, J Liu, S Sun - Pharmaceuticals, 2024 - mdpi.com
Currently, multiple myeloma (MM) is a prevalent hematopoietic system malignancy, known
for its insidious onset and unfavorable prognosis. Recently developed chemotherapy drugs …

Caspase‐driven cancer therapies: Navigating the bridge between lab discoveries and clinical applications

M Allani, Akhilesh, V Tiwari - Cell Biochemistry and Function, 2024 - Wiley Online Library
Apoptosis is the cell's natural intrinsic regulatory mechanism of normal cells for programmed
cell death, which plays an important role in cancer as a classical mechanism of tumor cell …

Amrubicin encapsulated PLGA NPs inhibits the PI3K/AKT signaling pathway by activating PTEN and inducing apoptosis in TMZ-resistant Glioma

M Younis, S Shaikh, KA Shahzad, F Tan… - Biomedical …, 2024 - iopscience.iop.org
Glioblastoma (GBM) remains a challenging malignancy due to its aggressive nature and the
lack of efficacious therapeutic interventions. Nanotechnology-based approaches exhibit …

WITHDRAWN: Long non-coding RNA RP5-821D11. 7 promotes proliferation, migration, and epithelial-mesenchymal transition in glioma and glioma stem-like cells

M Younis, S Shaikh, KA Shahzad - Progress in Biophysics and Molecular …, 2021 - Elsevier
WITHDRAWN: Long non-coding RNA RP5-821D11.7 promotes proliferation, migration, and
epithelial-mesenchymal transition in glioma and glioma stem-like cells - ScienceDirect Skip …

Exogenous HMGB1 promotes pancreatic cancer progression by supporting the crosstalk between tumor and myeloid-derived suppressor cell

F Wang, W Wei, T San, L Li - 2024 - researchsquare.com
Background The main reasons pancreatic cancer (PC) is difficult to treat are high tissue
fibrosis and a strong immunosuppressive microenvironment. Therefore, it is necessary to …