Will SARS-CoV-2 variants of concern affect the promise of vaccines?

RK Gupta - Nature Reviews Immunology, 2021 - nature.com
Initial optimism regarding the development of COVID-19 vaccines has been tempered by the
emergence of new variants of SARS-CoV-2. Will vaccination be able to contain the …

Emerging SARS-CoV-2 variants: a review of its mutations, its implications and vaccine efficacy

S Ramesh, M Govindarajulu, RS Parise, L Neel… - Vaccines, 2021 - mdpi.com
The widespread increase in multiple severe acute respiratory syndrome coronavirus-2
(SARS-CoV-2) variants is causing a significant health concern in the United States and …

Safety and immunogenicity of one versus two doses of the COVID-19 vaccine BNT162b2 for patients with cancer: interim analysis of a prospective observational study

L Monin, AG Laing, M Muñoz-Ruiz… - The Lancet …, 2021 - thelancet.com
Background The efficacy and safety profiles of vaccines against SARS-CoV-2 in patients
with cancer is unknown. We aimed to assess the safety and immunogenicity of the …

Immunogenicity of the BNT162b2 COVID-19 mRNA vaccine and early clinical outcomes in patients with haematological malignancies in Lithuania: a national …

K Maneikis, K Šablauskas, U Ringelevičiūtė… - The Lancet …, 2021 - thelancet.com
Background Haematological malignancies and their treatments are likely to affect SARS-
CoV-2 vaccine efficacy. We aimed to evaluate serological response to BNT162b2 vaccine in …

Central obesity, smoking habit, and hypertension are associated with lower antibody titres in response to COVID‐19 mRNA vaccine

M Watanabe, A Balena, D Tuccinardi… - Diabetes/metabolism …, 2022 - Wiley Online Library
Aims To explore variables associated with the serological response following COVID‐19
mRNA vaccine. Methods Eighty‐six healthcare workers adhering to the vaccination …

Vaccine effectiveness of the first dose of ChAdOx1 nCoV-19 and BNT162b2 against SARS-CoV-2 infection in residents of long-term care facilities in England (VIVALDI …

M Shrotri, M Krutikov, T Palmer, R Giddings… - The Lancet Infectious …, 2021 - thelancet.com
Background The effectiveness of SARS-CoV-2 vaccines in older adults living in long-term
care facilities is uncertain. We investigated the protective effect of the first dose of the Oxford …

SARS-CoV-2 ferritin nanoparticle vaccines elicit broad SARS coronavirus immunogenicity

MG Joyce, WH Chen, RS Sankhala, A Hajduczki… - Cell reports, 2021 - cell.com
The need for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) next-
generation vaccines has been highlighted by the rise of variants of concern (VoCs) and the …

Interim results of the safety and immune-efficacy of 1 versus 2 doses of COVID-19 vaccine BNT162b2 for cancer patients in the context of the UK vaccine priority …

L Monin-Aldama, AG Laing, M Muñoz-Ruiz… - MedRxiv, 2021 - medrxiv.org
Background The efficacy and safety profile of vaccines against severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) have not been definitively established in …

Profile of humoral and cellular immune responses to single doses of BNT162b2 or ChAdOx1 nCoV-19 vaccines in residents and staff within residential care homes …

G Tut, T Lancaster, M Krutikov, P Sylla… - The Lancet Healthy …, 2021 - thelancet.com
Background Residents of long-term care facilities (LTCFs) have been prioritised for COVID-
19 vaccination because of the high COVID-19 mortality in this population. Several countries …

Antibody and cellular immune responses following dual COVID-19 vaccination within infection-naive residents of long-term care facilities: an observational cohort …

G Tut, T Lancaster, P Sylla, MS Butler… - The Lancet Healthy …, 2022 - thelancet.com
Background Older age and frailty are risk factors for poor clinical outcomes following SARS-
CoV-2 infection. As such, COVID-19 vaccination has been prioritised for individuals with …