Cardiac arrhythmias can follow disruption of the normal cellular electrophysiological
processes underlying excitable activity and their tissue propagation as coherent wavefronts …

Hypokalemia is a common biochemical finding in cardiac patients and may represent a side
effect of diuretic therapy or result from endogenous activation of renin–angiotensin system …

QT interval, a surrogate measure for ventricular action potential duration (APD) in the
surface ECG, is widely used to identify cardiac abnormalities and drug safety. In humans …

The recently described exchange protein directly activated by cAMP (Epac) has been
implicated in distinct protein kinase A-independent cellular signalling pathways. We …

In cardiac patients, life‐threatening tachyarrhythmia is often precipitated by abnormal
changes in ventricular repolarization and refractoriness. Repolarization abnormalities …

Ventricular arrhythmias are the key underlying cause of sudden cardiac death, a common
cause of mortality and a significant public health burden. Insights into the …

Cardiac arrhythmias cause significant morbidity and mortality and pose a major public
health problem. They arise from disruptions in the normally orderly propagation of cardiac …

Action potential duration (APD) and conduction velocity restitution explain the dependence
of these parameters on the previous diastolic interval (DI). It is considered to be an adaptive …

Ventricular arrhythmic and electrophysiological properties were examined during
normokalaemia (5.2 mM [K+]), hypokalaemia (3 mM [K+]) or hypokalaemia in the presence …

Sudden cardiac death resulting from ventricular arrhythmogenesis is a leading cause of
mortality in the developed world, accounting for up to 400,000 deaths per year in the US …