Functions of ROS in macrophages and antimicrobial immunity

M Herb, M Schramm - Antioxidants, 2021 - mdpi.com
Reactive oxygen species (ROS) are a chemically defined group of reactive molecules
derived from molecular oxygen. ROS are involved in a plethora of processes in cells in all …

NADPH oxidases and oxidase crosstalk in cardiovascular diseases: novel therapeutic targets

Y Zhang, P Murugesan, K Huang, H Cai - Nature Reviews Cardiology, 2020 - nature.com
Reactive oxygen species (ROS)-dependent production of ROS underlies sustained
oxidative stress, which has been implicated in the pathogenesis of cardiovascular diseases …

Sources of vascular nitric oxide and reactive oxygen species and their regulation

J Tejero, S Shiva, MT Gladwin - Physiological reviews, 2019 - journals.physiology.org
Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …

NADPH oxidases: an overview from structure to innate immunity-associated pathologies

A Panday, MK Sahoo, D Osorio, S Batra - Cellular & molecular …, 2015 - nature.com
Oxygen-derived free radicals, collectively termed reactive oxygen species (ROS), play
important roles in immunity, cell growth, and cell signaling. In excess, however, ROS are …

NADPH oxidase in brain injury and neurodegenerative disorders

MW Ma, J Wang, Q Zhang, R Wang… - Molecular …, 2017 - Springer
Oxidative stress is a common denominator in the pathology of neurodegenerative disorders
such as Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral …

NADPH oxidase family proteins: signaling dynamics to disease management

R Begum, S Thota, A Abdulkadir, G Kaur… - Cellular & Molecular …, 2022 - nature.com
Reactive oxygen species (ROS) are pervasive signaling molecules in biological systems. In
humans, a lack of ROS causes chronic and extreme bacterial infections, while uncontrolled …

Reactive oxygen species regulate axonal regeneration through the release of exosomal NADPH oxidase 2 complexes into injured axons

A Hervera, F De Virgiliis, I Palmisano, L Zhou… - Nature cell …, 2018 - nature.com
Reactive oxygen species (ROS) contribute to tissue damage and remodelling mediated by
the inflammatory response after injury. Here we show that ROS, which promote axonal …

Vascular oxidative stress: impact and therapeutic approaches

CM Sena, A Leandro, L Azul, R Seiça… - Frontiers in physiology, 2018 - frontiersin.org
Oxidative stress has been defined as an imbalance between oxidants and antioxidants and
more recently as a disruption of redox signaling and control. It is generally accepted that …

Targeting oxidative stress as a therapeutic approach for idiopathic pulmonary fibrosis

C Estornut, J Milara, MA Bayarri, N Belhadj… - Frontiers in …, 2022 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease characterized by an
abnormal reepithelialisation, an excessive tissue remodelling and a progressive fibrosis …

Oxidative stress and pathophysiology of ischemic stroke: novel therapeutic opportunities

R Rodrigo, R Fernandez-Gajardo… - CNS & Neurological …, 2013 - ingentaconnect.com
Stroke is the second leading cause of death, after ischemic heart disease, and accounts for
9% of deaths worldwide. According to the World Health Organization [WHO], 15 million …