While continuous manufacturing (CM) of pharmaceutical solid-based drug products has
been shown to be advantageous for improving the product quality and process efficiency in …

Continuous manufacturing (CM) sends materials directly and continuously to the next step of
a process, eliminating hold times and reducing processing times. The potential benefits of …

The pharmaceutical industry is continuously overcoming ways to reduce its development
times to market and bring new medicines to patients with the highest quality standards …

Residence time distribution (RTD) models are essential to understand process dynamics
and support process monitoring and control in continuous manufacturing systems. RTD …

Residence time distributions (RTDs) are quickly becoming an important component of the
quality control strategy for continuous manufacturing (CM) of pharmaceutical products …

This work aims to expand the typical raw material attributes that can successfully be
processed on a continuous direct compression line with a particular focus on the continuous …

Residence time distribution (RTD) modeling can aid the understanding and characterization
of macro-mixing in continuous powder processing unit operations by relating observed …

In this paper we present a thorough description of the digital twin development for a
continuous pharmaceutical powder blending process in accordance with the Process …

Integrated flowsheet modeling is an engineering approach that can provide a framework for
understanding the impact of process dynamics on drug quality and associated risks during …

Continuous manufacturing (CM) offers quality and cost-effectiveness benefits over currently
dominating batch processing. One challenge that needs to be addressed when …