Breast cancer (BC) is the second most fatal disease and is the prime cause of cancer allied
female deaths. BC is caused by aberrant tumor suppressor genes and oncogenes regulated …

Breast cancer treatment using a single drug is associated with a high failure rate due, in part,
to the heterogeneity of drug response within individuals, nonspecific target action, drug …

Estrogen receptor alpha (ERα), a nuclear transcription factor, is a well-validated therapeutic
target for more than 70% of all breast cancers (BCs). Antagonizing ERα either by selective …

Macrophage-mediated inflammation drives autoimmune and chronic inflammatory diseases.
Treatment with anti-inflammatory agents can be an effective strategy to reduce this …

Hormone therapy targeting estrogen receptors is widely used clinically for the treatment of
breast cancer, such as tamoxifen, but most of them are partial agonists, which can cause …

Background The purpose of the study was to analyze the relationship between the caspase-
like (CL) and chymotrypsin-like (ChTL) activities of proteasomes and the 5-year overall and …

Cancer is a major disease worldwide and different approaches are needed to reduce its risk.
Previous laboratory studies suggested that cancer can be prevented by many naturally …

The incidence of autoimmune disease is increasing worldwide. Current treatments for
autoimmune disease are often life-long and associated with general immunosuppression …

Настоящее изобретение относится к медицине, а именно к онкологии, и касается
прогнозирования риска развития отдаленных метастазов у больных операбельными …