Neuroinflammation in Alzheimer's disease

IG Onyango, GV Jauregui, M Čarná, JP Bennett Jr… - Biomedicines, 2021 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disease associated with human aging.
Ten percent of individuals over 65 years have AD and its prevalence continues to rise with …

Clearance of cerebral Aβ in Alzheimer's disease: reassessing the role of microglia and monocytes

L Zuroff, D Daley, KL Black… - Cellular and Molecular …, 2017 - Springer
Deficiency in cerebral amyloid β-protein (Aβ) clearance is implicated in the pathogenesis of
the common late-onset forms of Alzheimer's disease (AD). Accumulation of misfolded Aβ in …

Alzheimer's retinopathy: seeing disease in the eyes

N Mirzaei, H Shi, M Oviatt, J Doustar… - Frontiers in …, 2020 - frontiersin.org
The neurosensory retina emerges as a prominent site of Alzheimer's disease (AD)
pathology. As a CNS extension of the brain, the neuro retina is easily accessible for …

Retinal vasculopathy in Alzheimer's disease

H Shi, Y Koronyo, A Rentsendorj, DT Fuchs… - Frontiers in …, 2021 - frontiersin.org
The retina has been increasingly investigated as a site of Alzheimer's disease (AD)
manifestation for over a decade. Early reports documented degeneration of retinal ganglion …

The aging eye: common degenerative mechanisms between the Alzheimer's brain and retinal disease

JM Sivak - Investigative ophthalmology & visual science, 2013 - iovs.arvojournals.org
Alzheimer's disease (AD) is a common, incurable, and progressive dementia, characterized
by loss of learning and memory and the neuropathologic accumulation of amyloid plaques …

Alzheimer's disease in the retina: imaging retinal aβ plaques for early diagnosis and therapy assessment

Y Koronyo, BC Salumbides, KL Black… - Neurodegenerative …, 2012 - karger.com
Abstract Background: Definite Alzheimer's disease (AD) diagnosis at early stages is vital for
targeting intervention, yet currently unavailable. Noninvasive detection of the pathological …

Glatiramer acetate immunomodulation: evidence of neuroprotection and cognitive preservation

A Kasindi, DT Fuchs, Y Koronyo, A Rentsendorj… - Cells, 2022 - mdpi.com
Novel, neuroprotective uses of Copaxone (generic name: glatiramer acetate—GA) are being
examined, primarily in neurological conditions involving cognitive decline. GA is a well …

A novel role for osteopontin in macrophage-mediated amyloid-β clearance in Alzheimer's models

A Rentsendorj, J Sheyn, DT Fuchs, D Daley… - Brain, behavior, and …, 2018 - Elsevier
Osteopontin (OPN), a matricellular immunomodulatory cytokine highly expressed by
myelomonocytic cells, is known to regulate immune cell migration, communication, and …

Therapeutic effects of glatiramer acetate and grafted CD115+ monocytes in a mouse model of Alzheimer's disease

Y Koronyo, BC Salumbides, J Sheyn, L Pelissier, S Li… - Brain, 2015 - academic.oup.com
Weekly glatiramer acetate immunization of transgenic mice modelling Alzheimer's disease
resulted in retained cognition (Morris water maze test), decreased amyloid-β plaque burden …

Angiotensin-converting enzyme overexpression in myelomonocytes prevents Alzheimer's-like cognitive decline

KE Bernstein, Y Koronyo… - The Journal of …, 2014 - Am Soc Clin Investig
Cognitive decline in patients with Alzheimer's disease (AD) is associated with elevated brain
levels of amyloid β protein (Aβ), particularly neurotoxic Aβ1–42. Angiotensin-converting …