The development of anticancer ruthenium (II) complexes: from single molecule compounds to nanomaterials

L Zeng, P Gupta, Y Chen, E Wang, L Ji… - Chemical Society …, 2017 - pubs.rsc.org
Cancer is rapidly becoming the top killer in the world. Most of the FDA approved anticancer
drugs are organic molecules, while metallodrugs are very scarce. The advent of the first …

[HTML][HTML] G-quadruplex DNA targeted metal complexes acting as potential anticancer drugs

Q Cao, Y Li, E Freisinger, PZ Qin, RKO Sigel… - Inorganic Chemistry …, 2017 - pubs.rsc.org
Although cisplatin and its analogues have been widely utilized as anticancer metallodrugs
in clinics, their serious side effects and damage to normal tissues cannot be avoided …

Monomeric and dimeric coordinatively saturated and substitutionally inert Ru (II) polypyridyl complexes as anticancer drug candidates

A Notaro, G Gasser - Chemical Society Reviews, 2017 - pubs.rsc.org
Due to the increasing impact of cancer on worldwide mortality, more and more attention is
being devoted to the investigation of novel anticancer strategies. Among these …

Water-soluble ruthenium (II) complexes with chiral 4-(2, 3-dihydroxypropyl)-formamide oxoaporphine (FOA): in vitro and in vivo anticancer activity by stabilization of G …

ZF Chen, QP Qin, JL Qin, J Zhou, YL Li… - Journal of Medicinal …, 2015 - ACS Publications
Three water-soluble ruthenium (II) complexes with chiral 4-(2, 3-dihydroxypropyl)-formamide
oxoaporphine (FOA) were synthesized and characterized. It was found that these ruthenium …

Detailed account on activation mechanisms of ruthenium coordination complexes and their role as antineoplastic agents

M Pal, U Nandi, D Mukherjee - European Journal of Medicinal Chemistry, 2018 - Elsevier
Ruthenium (Ru) complexes are known for their promising anticancer activity presumably
due to octahedral coordination geometry, slow ligand exchange rate, the range of different …

[HTML][HTML] Learning to model G-quadruplexes: current methods and perspectives

I Ortiz de Luzuriaga, X Lopez… - Annual Review of …, 2021 - annualreviews.org
G-quadruplexes have raised considerable interest during the past years for the development
of therapies against cancer. These noncanonical structures of DNA may be found in …

Towards the Development of Photo‐Reactive Ruthenium (II) Complexes Targeting Telomeric G‐Quadruplex DNA

J Weynand, A Diman, M Abraham… - … A European Journal, 2018 - Wiley Online Library
The design and characterization of new ruthenium (II) complexes aimed at targeting G‐
quadruplex DNA is reported. Importantly, these complexes are based on oxidizing 1, 4, 5, 8 …

Enhanced G-quadruplex DNA stabilization and telomerase inhibition by novel fluorescein derived salen and salphen based Ni (II) and Pd (II) complexes

A Ali, M Kamra, S Roy, K Muniyappa… - Bioconjugate …, 2017 - ACS Publications
Metal based salen complexes have been considered as an important scaffold toward
targeting of DNA structures. In the present work, we have synthesized nickel (II) and …

[HTML][HTML] An overview of the potential medicinal and pharmaceutical properties of Ru (II)/(III) complexes

A Skoczynska, A Lewinski, M Pokora, P Paneth… - International Journal of …, 2023 - mdpi.com
This review examines the existing knowledge about Ru (II)/(III) ion complexes with a
potential application in medicine or pharmacy, which may offer greater potential in cancer …

Dinuclear Ruthenium (II) Complexes That Induce and Stabilise G‐Quadruplex DNA

L Xu, X Chen, J Wu, J Wang, L Ji… - Chemistry–A European …, 2015 - Wiley Online Library
A series of dinuclear ruthenium (II) complexes were synthesised, and the complexes were
determined to be new highly selective compounds for binding to telomeric G‐quadruplex …