Immediate‐early gene regulation by interplay between different post‐translational modifications on human histone H3

A Kaleem, DC Hoessli, I Ahmad… - Journal of Cellular …, 2008 - Wiley Online Library
In mammalian cells, induction of immediate‐early (IE) gene transcription occurs
concomitantly with histone H3 phosphorylation on Ser 10 and is catalyzed by mitogen …

MAPRes: Mining association patterns among preferred amino acid residues in the vicinity of amino acids targeted for post‐translational modifications

I Ahmad, WM Qazi, A Khurshid, M Ahmad… - …, 2008 - Wiley Online Library
Post‐translational modification (PTM) of a protein is an important event in regulating cellular
functions. An algorithm, MAPRes, has been developed for mining associations among PTM …

In silico modulation of apoptotic Bcl‐2 proteins by mistletoe lectin‐1: Functional consequences of protein modifications

TA Khwaja, T Wajahat, I Ahmad… - Journal of cellular …, 2008 - Wiley Online Library
Abstract The mistletoe lectin‐1 (ML‐1) modulates tumor cell apoptosis by triggering
signaling cascades through the complex interplay of phosphorylation and O‐linked N …

Phosphoproteome sequence analysis and significance: mining association patterns around phosphorylation sites utilizing MAPRes

I Ahmad, A Mehmood, A Khurshid… - Journal of cellular …, 2009 - Wiley Online Library
Phosphorylation, one of the most common protein post‐translational modifications (PTMs)
on hydroxyl groups of S/T/Y is catalyzed by kinases and involves the presence or absence of …

Exploring the Sequence Context of Phosphorylatable Amino Acids: The Contribution of the Upgraded MAPRes Tool

Z Iqbal, DC Hoessli, WM Qazi, M Ahmad… - Journal of Cellular …, 2015 - Wiley Online Library
Several models that predict where post‐translational modifications are likely to occur and
formulate the corresponding association rules are available to analyze the functional …