Lipid nanoparticle (LNP) enables mRNA delivery for cancer therapy
Messenger RNA (mRNA) has received great attention in the prevention and treatment of
various diseases due to the success of coronavirus disease 2019 (COVID‐19) mRNA …
various diseases due to the success of coronavirus disease 2019 (COVID‐19) mRNA …
PEGylated lipid nanoparticle formulations: immunological safety and efficiency perspective
Lipid nanoparticles (LNPs) have been recognized as efficient vehicles to transport a large
variety of therapeutics. Currently in the spotlight as important constituents of the COVID-19 …
variety of therapeutics. Currently in the spotlight as important constituents of the COVID-19 …
Impact of anti-PEG antibodies induced by SARS-CoV-2 mRNA vaccines
Y Ju, JM Carreño, V Simon, K Dawson… - Nature Reviews …, 2023 - nature.com
The successful mRNA vaccines against COVID-19 contain polyethylene glycol (PEG) to
stabilize the lipid nanoparticles. Recent data show that PEG-specific antibodies can be …
stabilize the lipid nanoparticles. Recent data show that PEG-specific antibodies can be …
Immunogenicity of lipid nanoparticles and its impact on the efficacy of mRNA vaccines and therapeutics
Several studies have utilized a lipid nanoparticle delivery system to enhance the
effectiveness of mRNA therapeutics and vaccines. However, these nanoparticles are …
effectiveness of mRNA therapeutics and vaccines. However, these nanoparticles are …
[HTML][HTML] Lipid nanoparticles for delivery of RNA therapeutics: Current status and the role of in vivo imaging
Lipid nanoparticles (LNPs) have been one of the most successful nano-delivery vehicles
that enable efficient delivery of cytotoxic chemotherapy agents, antibiotics, and nucleic acid …
that enable efficient delivery of cytotoxic chemotherapy agents, antibiotics, and nucleic acid …
PEGylated therapeutics in the clinic
The covalent attachment of polyethylene glycol (PEG) to therapeutic agents, termed
PEGylation, is a well‐established and clinically proven drug delivery approach to improve …
PEGylation, is a well‐established and clinically proven drug delivery approach to improve …
The mRNA vaccine revolution: COVID-19 has launched the future of vaccinology
During the COVID-19 pandemic, mRNA (mRNA) vaccines emerged as leading vaccine
candidates in a record time. Nonreplicating mRNA (NRM) and self-amplifying mRNA (SAM) …
candidates in a record time. Nonreplicating mRNA (NRM) and self-amplifying mRNA (SAM) …
Engineering poly (ethylene glycol) nanoparticles for accelerated blood clearance inhibition and targeted drug delivery
Surface modification with poly (ethylene glycol)(PEGylation) is an effective strategy to
improve the colloidal stability of nanoparticles (NPs) and is often used to minimize cellular …
improve the colloidal stability of nanoparticles (NPs) and is often used to minimize cellular …
Knife's edge: Balancing immunogenicity and reactogenicity in mRNA vaccines
Since the discovery of messenger RNA (mRNA), there have been tremendous efforts to
wield them in the development of therapeutics and vaccines. During the COVID-19 …
wield them in the development of therapeutics and vaccines. During the COVID-19 …
Controlling the biodistribution and clearance of nanomedicines
Nanomedicines improve drug bioavailability, the dose–response relationship, targeting
ability, efficacy and safety compared to conventional freely administered drugs …
ability, efficacy and safety compared to conventional freely administered drugs …