Defensins are a well-characterised group of small, disulphide-rich, cationic peptides that are
produced by essentially all eukaryotes and are highly diverse in their sequences and …

BACKGROUND Reproductive tract infection is an important factor leading to male and
female infertility. Among female infertility factors, microbial and viral infections are the main …

There is a pressing need to develop new antiviral treatments; of the 60 drugs currently
available, half are aimed at HIV-1 and the remainder target only a further six viruses. This …

Defensins represent an evolutionary ancient family of antimicrobial peptides that play
diverse roles in human health and disease. Defensins are cationic cysteine-containing …

Objectives We evaluated the importance of ethnicity and pharmacogenetic variations in
determining efavirenz pharmacokinetics, auto-induction and immunological outcomes in two …

Recent analysis of the bovine genome revealed an expanded suite of β-defensin genes that
encode what are referred to as antimicrobial or host defense peptides (HDPs). Whereas …

Urinary tract infections (UTIs), including pyelonephritis, are among the most common and
serious infections encountered in nephrology practice. UTI risk is increased in selected …

Variability in the susceptibility to infectious disease and its clinical manifestation can be
determined by variation in the environment and by genetic variation in the pathogen and the …

Recent studies in human immunodeficiency virus (HIV) have garnered interest for the role of
CC chemokine receptor 6 (CCR6) and its known ligands, CC chemokine ligand 20 (CCL20) …

Human beta-defensins (hBDs) are broad-spectrum antimicrobial peptides, secreted by
epithelial cells of the skin and mucosae, and astrocytes, which we and others have shown to …