Preeclampsia: pathophysiology, challenges, and perspectives

S Rana, E Lemoine, JP Granger… - Circulation …, 2019 - Am Heart Assoc
Hypertensive disorders of pregnancy—chronic hypertension, gestational hypertension, and
preeclampsia—are uniquely challenging as the pathology and its therapeutic management …

Pre-eclampsia: pathogenesis, novel diagnostics and therapies

EA Phipps, R Thadhani, T Benzing… - Nature Reviews …, 2019 - nature.com
Pre-eclampsia is a complication of pregnancy that is associated with substantial maternal
and fetal morbidity and mortality. The disease presents with new-onset hypertension and …

Vascular dysfunction in preeclampsia

MA Opichka, MW Rappelt, DD Gutterman, JL Grobe… - Cells, 2021 - mdpi.com
Preeclampsia is a life-threatening pregnancy-associated cardiovascular disorder
characterized by hypertension and proteinuria at 20 weeks of gestation. Though its exact …

Neurodevelopmental outcomes of prenatal preeclampsia exposure

SB Gumusoglu, ASS Chilukuri, DA Santillan… - Trends in …, 2020 - cell.com
Preeclampsia is a dangerous hypertensive disorder of pregnancy with known links to
negative child health outcomes. Here, we review epidemiological and basic neuroscience …

Rodent models of hypertension

HA Jama, RR Muralitharan, C Xu… - British Journal of …, 2022 - Wiley Online Library
Elevated blood pressure (BP), or hypertension, is the main risk factor for cardiovascular
disease. As a multifactorial and systemic disease that involves multiple organs and systems …

Methods for the Comprehensive in vivo Analysis of Energy Flux, Fluid Homeostasis, Blood Pressure, and Ventilatory Function in Rodents

JJ Reho, P Nakagawa, GC Mouradian Jr… - Frontiers in …, 2022 - frontiersin.org
Cardiovascular disease represents the leading cause of death in the United States, and
metabolic diseases such as obesity represent the primary impediment to improving …

Antidiuretic hormone and serum osmolarity physiology and related outcomes: what is old, what is new, and what is unknown?

M Kanbay, S Yilmaz, N Dincer, A Ortiz… - The Journal of …, 2019 - academic.oup.com
Context Although the physiology of sodium, water, and arginine vasopressin (AVP), also
known as antidiuretic hormone, has long been known, accumulating data suggest that this …

Animal models of cardiovascular complications of pregnancy

Z Arany, D Hilfiker-Kleiner, SA Karumanchi - Circulation research, 2022 - Am Heart Assoc
Cardiovascular complications of pregnancy have risen substantially over the past decades,
and now account for the majority of pregnancy-induced maternal deaths, as well as having …

Animal models of preeclampsia: mechanistic insights and promising therapeutics

EB Taylor, EM George - Endocrinology, 2022 - academic.oup.com
Preeclampsia (PE) is a common pregnancy-specific disorder that is a major cause of both
maternal and fetal morbidity and mortality. Central to the pathogenesis of PE is the …

Flavonoids exert potential in the management of hypertensive disorders in pregnancy

A Mazurakova, L Koklesova, M Samec, E Kudela… - Pregnancy …, 2022 - Elsevier
Hypertensive disorders in pregnancy represent severe complications of pregnancy, which, if
not treated, can result in serious health consequences for the mother and the child …