▪ Abstract The yeast SIR protein complex has been implicated in transcription silencing and
suppression of recombination. The Sir complex represses transcription at telomeres, mating …

▪ Abstract Genomes are organized into active regions known as euchromatin and inactive
regions known as heterochromatin, or silenced chromatin. This review describes …

Synthetic biology enables the design of gene networks to confer specific biological
functions, yet it remains a challenge to rationally engineer a biological trait as complex as …

Mammalian cells contain 100 or more copies of tandemly repeated ribosomal RNA (rRNA)
genes per haploid genome. These genes are transcribed with high efficiency to keep up with …

Although NAD+ biosynthesis is required for Sir2 functions and replicative lifespan in yeast,
alterations in NAD+ precursors have been reported to accelerate aging but not to extend …

Intracellular energy balance is important for cell survival. In eukaryotic cells, the most energy-
consuming process is ribosome biosynthesis, which adapts to changes in intracellular …

It is known that mutations in gene SIR2 increase and those in FOB1 decrease recombination
within rDNA repeats as assayed by marker loss or extrachromosomal rDNA circle formation …

Transcriptional silencing in Saccharomyces cerevisiae occurs at several genomic sites
including the silent mating-type loci, telomeres, and the ribosomal DNA (rDNA) tandem …

Nucleolar dominance describes the silencing of one parental set of ribosomal RNA (rRNA)
genes in a genetic hybrid, an epigenetic phenomenon that occurs on a scale second only to …

Silencing within the yeast rDNA repeats inhibits hyperrecombination, represses transcription
from foreign promoters, and extends replicative life span. rDNA silencing is mediated by a …