[HTML][HTML] Genetically regulated gene expression in the brain associated with chronic pain: Relationships with clinical traits and potential for drug repurposing
Background Chronic pain is a common, poorly understood condition. Genetic studies
including genome-wide association studies have identified many relevant variants, which …
including genome-wide association studies have identified many relevant variants, which …
Application of polygenic scores to a deeply phenotyped sample enriched for substance use disorders reveals extensive pleiotropy with psychiatric and somatic traits
EE Hartwell, Z Jinwala, J Milone, S Ramirez… - …, 2024 - nature.com
Co-occurring psychiatric, medical, and substance use disorders (SUDs) are common, but
the complex pathways leading to such comorbidities are poorly understood. A greater …
the complex pathways leading to such comorbidities are poorly understood. A greater …
Repurposing antihypertensive drugs for pain disorders: a drug-target mendelian randomization study
K Du, A Li, CY Zhang, SM Li, P Chen - Frontiers in Pharmacology, 2024 - frontiersin.org
Objective Addressing the rising prevalence of pain disorders and limitations of current
analgesics, our study explores repurposing antihypertensive drugs for pain management …
analgesics, our study explores repurposing antihypertensive drugs for pain management …
Repurposing antihypertensive and statin medications for spinal pain: a Mendelian randomization study
Study Design. Mendelian randomization (MR) study. Objective. To examine whether
antihypertensive medications (beta-blockers, calcium channel blockers, and angiotensin …
antihypertensive medications (beta-blockers, calcium channel blockers, and angiotensin …
[HTML][HTML] A Multivariate Genome-Wide Association Study Reveals Neural Correlates and Common Biological Mechanisms of Psychopathology Spectra
There is considerable comorbidity across externalizing and internalizing behavior
dimensions of psychopathology. We applied genomic structural equation modeling (gSEM) …
dimensions of psychopathology. We applied genomic structural equation modeling (gSEM) …