Metabotropic glutamate (mGlu) receptors are G-protein-coupled receptors expressed
primarily on neurons and glial cells, where they are located in the proximity of the synaptic …

Major depressive disorder (MDD) is a common, chronic, recurrent mental illness that affects
millions of individuals worldwide. Currently available antidepressants are known to affect the …

The anterior pituitary gland drives highly conserved physiologic processes in mammalian
species. These hormonally controlled processes are central to somatic growth, pubertal …

Dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis has been implicated in a
range of affective and stress-related disorders. The regulatory systems that control HPA …

Fibromyalgia is considered a stress‐related disorder, and hypo‐as well as hyperactive
stress systems (sympathetic nervous system and hypothalamic‐pituitary‐adrenal axis) have …

The spiral ganglion neurons (SGNs) are the first action potential generating neurons in the
auditory pathway. The type I SGNs contact the sensory inner hair cells via their peripheral …

Mitchell ND, Baker GB. An update on the role of glutamate in the pathophysiology of
depression. Objective: To review the literature on the involvement of glutamate (Glu) …

Perampanel is a novel α-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor
(AMPAR) antagonist, approved in over 35 countries as an adjunctive therapy for the …

Anxiety disorders are amongst the most common and disabling of psychiatric illnesses and
have severe health and socio-economic implications. Despite the availability of a number of …

Early models for the etiology of schizophrenia focused on dopamine neurotransmission
because of the powerful anti‐psychotic action of dopamine antagonists. Nevertheless …