Forkhead Box G1 (FOXG1) is a member of the Forkhead family of genes with non-redundant
roles in brain development, where alteration of this gene's expression significantly affects …

Forkhead box (FOX) proteins are an evolutionarily conserved family of transcription factors
that play numerous regulatory roles in eukaryotes during developmental and adult life …

Importance Children with medical complexity (CMC) represent a growing population in the
pediatric health care system, with high resource use and associated health care costs. A …

Background Rett syndrome (RTT) is a severe neurodevelopmental disorder with complex
medical comorbidities extending beyond the nervous system requiring the attention of health …

Individuals with mutations in forkhead box G1 (FOXG1) belong to a distinct clinical entity,
termed “FOXG1-related encephalopathy”. There are two clinical phenotypes/syndromes …

Brain organoids have rapidly become established as promising tools for studying both the
normal embryonic development of the brain and the mechanistic roots of …

Rett Syndrome (RTT) is a rare and severe X-linked developmental brain disorder that occurs
primarily in females, with a ratio of 1: 10.000. De novo mutations in the Methyl-CpG Binding …

Autism spectrum disorder (ASD) is frequently associated with infants with epileptic
encephalopathy, and early interventions targeting social and cognitive deficits can have …

The mammalian neocortex is a highly organized six-layered structure with four major cortical
neuron subtypes: corticothalamic projection neurons (CThPNs), subcerebral projection …

Abstract Development of the central nervous system (CNS) is a complex, dynamic process
that involves a precisely orchestrated sequence of genetic, environmental, biochemical, and …