This review highlights the complex role of fatty acid β-oxidation in brain metabolism. It
demonstrates the fundamental importance of fatty acid degradation as a fuel in energy …

Antioxidant defenses in biological systems ensure redox homeostasis, regulating baseline
levels of reactive oxygen and nitrogen species (ROS and RNS). Oxidative stress (OS) …

Background The accumulation and aggregation of α‐synuclein (α‐Syn) are characteristic of
Parkinson's disease (PD). Epidemiological evidence indicates that hyperlipidemia is …

Gingipains are protease virulence factors produced by Porphyromonas gingivalis, a Gram-
negative bacterium best known for its role in chronic periodontitis. Gingipains were recently …

Hundreds of pathogenic variants of mitochondrial DNA (mtDNA) have been reported to
cause mitochondrial diseases, which still lack effective treatments. It is a huge challenge to …

Mitochondrial Complex I dysfunction and oxidative stress have been part of the
pathophysiology of several diseases ranging from mitochondrial disease to chronic …

Network analysis of functional brain scans acquired with [18 F]-fluorodeoxyglucose positron
emission tomography (FDG PET, to map cerebral glucose metabolism), or resting-state …

Parkinson's disease is the second most common neurodegenerative disease. Unfortunately,
there is still no definitive disease-modifying therapy. In our work, the antiparkinsonian …

Understanding the pathophysiology of neurological symptoms observed after severe acute
respiratory syndrome coronavirus 2 (SARS-CoV2) infection is essential to optimizing …

Parkinson's disease (PD) is a multifactorial neurodegenerative disease characterized by the
loss of dopaminergic neurons in the midbrain. In the prodromal phase several autonomic …