Introduction The overall goal of the Alzheimer's Disease Neuroimaging Initiative (ADNI) is to
validate biomarkers for Alzheimer's disease (AD) clinical trials. ADNI is a multisite …

The therapeutic potential of the dental pulp stem (DSC) cell-derived secretome, consisting of
various biomolecules, is undergoing intense research. Despite promising in vitro and in vivo …

Glia have been implicated in Alzheimer's disease (AD) pathogenesis. Variants of the
microglia receptor triggering receptor expressed on myeloid cells 2 (TREM2) increase AD …

INTRODUCTION The choroid plexus is a secretory epithelial tissue of the central nervous
system (CNS) responsible for cerebrospinal fluid (CSF) production and functions as a barrier …

Objective To examine the association between systemic inflammation measured during
midlife and 20-year cognitive decline. Methods Within the Atherosclerosis Risk in …

The capability to spatially explore RNA biology in formalin-fixed paraffin-embedded (FFPE)
tissues holds transformative potential for histopathology research. Here, we present …

Clinical evidence has established that concomitant traumatic brain injury (TBI) accelerates
bone healing, but the underlying mechanism is unclear. This study shows that after TBI …

The plasma proteomic changes that precede the onset of dementia could yield insights into
disease biology and highlight new biomarkers and avenues for intervention. We quantified …

Recent genetic studies have identified variants associated with bipolar disorder (BD), but it
remains unclear how brain gene expression is altered in BD and how genetic risk for BD …

Glaucoma is a chronic disease that shares many similarities with other neurodegenerative
disorders of the central nervous system. This study was designed to evaluate the association …