Hypertension contributes significantly to worldwide cardiovascular morbidity and mortality.
Hypertension appears to have a complex association with endothelial dysfunction, a …

Aldosterone, a steroid hormone with mineralocorticoid activity, is mainly recognized for its
action on sodium reabsorption in the distal nephron of the kidney, which is mediated by the …

Aldosterone mediates actions of the renin-angiotensin-aldosterone system inducing
hypertension, oxidative stress, and vascular inflammation. Recently, we showed that …

Aldosterone causes nongenomic vasoconstriction by activating phospholipase C in
preglomerular afferent arterioles. 18 The endothelium may modulate this vasoconstrictor …

Aldosterone exerts direct effects on the vascular system by inducing oxidative stress,
inflammation, hypertrophic remodeling, fibrosis, and endothelial dysfunction. Aldosterone …

Aldosterone concentrations are inappropriately high in many patients with hypertension, as
well as in an increasing number of individuals with metabolic syndrome and sleep apnoea …

The identity of the putative G-protein coupled receptor (GPCR) that mediates the non-
genomic effects of androgens is unknown. We present in vitro and in vivo evidence that the …

The mineralocorticoid receptor (MR), a member of the steroid receptor family, regulates
blood pressure by mediating the effects of the hormone aldosterone (Aldo) on renal sodium …

Aldosterone induces oxidative stress, endothelial dysfunction, inflammation and fibrosis in
the vasculature, heart and kidney. While most of these effects appear to be mediated via the …

Aldosterone has physiological effects to regulate fluid and electrolyte homeostasis across
epithelia and proinflammatory effects on a variety of nonepithelial cells in the context of …