Consideration of sex and gender differences in addiction medication response

SA McKee, AL McRae-Clark - Biology of sex Differences, 2022 - Springer
Substance use continues to contribute to significant morbidity and mortality in the United
States, for both women and men, more so than any other preventable health condition. To …

Off-label and investigational drugs in the treatment of alcohol use disorder: A critical review

PV Fischler, M Soyka, E Seifritz… - Frontiers in …, 2022 - frontiersin.org
Compounds known to be successful in the treatment of alcohol use disorder include the
aversive agent, Disulfiram, the glutamatergic NMDA receptor antagonist, Acamprosate, and …

A narrative review of current and emerging trends in the treatment of alcohol use disorder

M Celik, MS Gold, B Fuehrlein - Brain Sciences, 2024 - mdpi.com
Alcohol use disorder (AUD) is a significant contributor to morbidity and mortality in the
United States. It contributes to over 140,000 annual deaths, to over 200 related diseases …

Pharmacotherapies and personalized medicine for alcohol use disorder: a review

FW Lohoff - Pharmacogenomics, 2020 - Taylor & Francis
Alcohol use disorder (AUD) is highly prevalent and among the leading causes of morbidity
and mortality in the United States. Pharmacotherapies for AUD are limited, thus making …

Medication development for alcohol use disorder: a focus on clinical studies

L Leggio, DE Falk, ML Ryan, J Fertig… - Substance Use Disorders …, 2020 - Springer
Compared to other medical disorders, including other brain diseases, the number of
medications approved for alcohol use disorder (AUD) is very small. Disulfiram, naltrexone …

Variation in the serotonin transporter gene and alcoholism: risk and response to pharmacotherapy

MD Thompson, GA Kenna - Alcohol and Alcoholism, 2016 - academic.oup.com
SLC6A4, the gene encoding the serotonin transporter protein (5-HTT), has been extensively
examined as a risk factor for alcohol dependence (AD). More recently, variability in the …

Pharmacogenetics of alcohol use disorder treatments: an update

EE Hartwell, HR Kranzler - Expert opinion on drug metabolism & …, 2019 - Taylor & Francis
Introduction: Alcohol use disorder (AUD) is highly prevalent; costly economically, socially,
and interpersonally; and grossly undertreated. The low rate of utilization of medications with …

Parsing out the role of dopamine D4 receptor gene (DRD4) on alcohol‐related phenotypes: A meta‐analysis and systematic review

AM Daurio, SL Deschaine, A Modabbernia… - Addiction …, 2020 - Wiley Online Library
Genetics account for moderate variation of individual differences in developing alcohol use
disorder (AUD), but it is unclear which genetic variations contribute to AUD risk. One …

Advances in pharmacotherapy development: human clinical studies

RZ Litten, DE Falk, ML Ryan, J Fertig… - The Neuropharmacology of …, 2018 - Springer
For more than 25 years, researchers have made advances in developing medications to
treat alcohol use disorder (AUD), highlighted by the US Food and Drug Administration's …

Parental problem drinking and maladaptive personality features in children: The role of marital conflict

PS Keller, TA Widiger, M El-Sheikh - Child Psychiatry & Human …, 2023 - Springer
The personality characteristics of children of exposed to parental problem drinking have
been of interest to clinicians and researchers for several decades, but personality research …