A growing number of diseases seem to be associated with inappropriate deposition of
protein aggregates. Some of these diseases—such as Alzheimer's disease and systemic …

Transmissible spongiform encephalopathies (TSEs) are inevitably lethal neurodegenerative
diseases that affect humans and a large variety of animals. The infectious agent responsible …

Human sleeping sickness in east Africa is caused by the parasite Trypanosoma brucei
rhodesiense. The basis of this pathology is the resistance of these parasites to lysis by …

Prions have been responsible for an entire century of tragic episodes. Fifty years ago, kuru
decimated the population of Papua New Guinea. Then, iatrogenic transmission of prions …

Prion diseases such as Creutzfeldt–Jakob disease (CJD) are fatal, neuro-degenerative
disorders with no known therapy. A proportion of the UK population has been exposed to a …

Transmissible spongiform encephalopathies (TSEs) are neurodegenerative diseases that
are caused by prions and affect humans and many animal species. It is now widely accepted …

Prion diseases are transmissible, invariably fatal, neurodegenerative diseases which
include Creutzfeldt–Jakob disease (CJD) in humans and bovine spongiform …

Individuals infected with prions succumb to brain damage, and prion infections continue to
be inexorably lethal. However, many crucial steps in prion pathogenesis occur in lymphatic …

This review provides an update on the epidemiology of scrapie. The authors provide
historical and recent information regarding the determination of geographical distribution …

The outbreak of new variant Creutzfeldt-Jakob disease has raised the specter of a
potentially large population being at risk to develop this prionosis. None of the prionoses …