Rationale: The recent development of hyperpolarized 13C magnetic resonance
spectroscopy has made it possible to measure cellular metabolism in vivo, in real time …

Hyperpolarization is an emerging method in magnetic resonance imaging that allows
nuclear spin polarization of gases or liquids to be temporarily enhanced by up to five or six …

Musk, secreted by adult male forest musk deer, is a kind of precious Chinese traditional
medicine for treating cardiovascular, cerebrovascular and neurogenic diseases. However, a …

This study aimed to investigate real-time early detection of metabolic alteration in a rat
model with acute myocardial ischemia-reperfusion (AMI/R) injury and myocardial necrosis …

The use of hyperpolarised 13C pyruvate for nononcological neurological applications has
not been widespread so far, possibly due to delivery issues limiting the visibility of …

Traumatic brain injury (TBI) involves complex secondary injury processes following the
primary injury. The secondary injury is often associated with rapid metabolic shifts and …

The aim of this study was to acquire the transient MRI signal of hyperpolarized tracers and
their metabolites efficiently, for which specialized imaging sequences are required. In this …

The signal enhancement provided by the hyperpolarization of nuclear spins of biological
molecules is a highly promising technique for diagnostic imaging. To date, most 13C …

Purpose Noninvasive imaging with hyperpolarized (HP) pyruvate can capture in vivo cardiac
metabolism. For proper quantification of the metabolites and optimization of imaging …

The in vivo assessment of tissue metabolism represents a novel strategy for the evaluation
of oncologic disease. Hepatocellular carcinoma (HCC) is a high-prevalence, high-mortality …