The complement system is a recognized pillar of host defence against infection and noxious
self-derived antigens. Complement is traditionally known as a serum-effective system …

Complement is a complex innate immune surveillance system, playing a key role in defense
against pathogens and in host homeostasis. The complement system is initiated by …

Skeletal muscle conveys several of the health-promoting effects of exercise; yet the
underlying mechanisms are not fully elucidated. Studying skeletal muscle is challenging due …

The complement system plays a crucial role in the innate defense against common
pathogens. Activation of complement leads to robust and efficient proteolytic cascades …

Since its discovery in the 19th century, the complement system has developed into a
clinically significant entity. The complement system has been implicated in a variety of …

Gangliosides are structurally and functionally polymorphic sialic acid containing
glycosphingolipids that are widely distributed in the human body. They play important roles …

Exosomes are a type of extracellular vesicle whose study has grown exponentially in recent
years. This led to the understanding that these structures, far from being inert waste by …

The complement system is central to first-line defense against invading pathogens.
However, excessive complement activation and/or the loss of complement regulation …

Generalized myasthenia gravis (gMG) is a rare autoimmune disorder characterized by
skeletal muscle weakness caused by disrupted neurotransmission at the neuromuscular …

We present a simple yet powerful method for the isolation and analysis of exosomes
released by antigen-presenting cells (APC). Exosomes are small vesicles (40–90 nm) …