Proteomic analysis of cells, tissues and body fluids has generated valuable insights into the
complex processes influencing human biology. Proteins represent intermediate phenotypes …

The extreme diversity of the human immune system, forged and maintained throughout
evolutionary history, provides a potent defense against opportunistic pathogens. At the same …

Viral infection outcomes are sex biased, with males generally more susceptible than
females. Paradoxically, the numbers of antiviral natural killer (NK) cells are increased in …

The immune system is a complex network of cells with critical functions in health and
disease. However, a comprehensive census of the cells comprising the immune system is …

Pediatric coronavirus disease 2019 (COVID-19) after SARS-CoV-2 infection is associated
with fewer hospitalizations and often milder disease than in adults. A subset of children …

Differences in immune function and responses contribute to health-and life-span disparities
between sexes. However, the role of sex in immune system aging is not well understood …

Epidemiological data suggest that early life exposures are key determinants of immune-
mediated disease later in life. Young children are also particularly susceptible to infections …

We report on the influence of~ 22 million variants on 731 immune cell traits in a cohort of
3,757 Sardinians. We detected 122 significant (P< 1.28× 10− 11) independent association …

Immune responses generally decline with age. However, the dynamics of this process at the
individual level have not been characterized, hindering quantification of an individual's …

Understanding how human genetics influence infectious disease susceptibility offers the
opportunity for new insights into pathogenesis, potential drug targets, risk stratification …