The Rickettsiales are a group of obligate intracellular vector-borne Gram-negative bacteria
that include many organisms of clinical and agricultural importance, including Anaplasma …

It is estimated that approximately one billion people are at risk of infection with obligate
intracellular bacteria, but little is known about the underlying mechanisms that govern their …

Activating inflammatory caspases and releasing pro-inflammatory mediators are two
essential functions of inflammasomes which are triggered in response to pathogen …

Pathogenic bacteria secrete a variety of proteins that manipulate host cell function by
targeting components of the plasma membrane, cytosol, or organelles. In the last decade …

Many pathogens are transmitted by tick bites, including Anaplasma spp., Ehrlichia spp.,
Rickettsia spp., Babesia and Theileria sensu stricto species. These pathogens cause …

The host-pathogen interface is a crucial battleground during bacterial infection in which host
defenses are met with an array of bacterial counter-mechanisms whereby the invader aims …

Ehrlichia chaffeensis TRP120 effector has evolved short linear motif (SLiM) ligand mimicry to
repurpose multiple evolutionarily conserved cellular signaling pathways, including Wnt …

Abstract Background The genus Ehrlichia consists of tick-borne obligatory intracellular
bacteria that can cause deadly diseases of medical and agricultural importance. Ehrlichia …

Ehrlichia chaffeensis (E. chaffeensis) has evolved eukaryotic ligand mimicry to repurpose
multiple cellular signaling pathways for immune evasion. In this investigation, we …

Ticks are arthropods distributed worldwide that constitute the most important vectors of
diseases to animals, and second to mosquitoes regarding pathogens of public health …