Streptococcus pneumoniae (the pneumococcus) is an important human pathogen. Its
virulence is largely due to its polysaccharide capsule, which shields it from the host immune …

Asplenia (the congenital or acquired absence of the spleen) and hyposplenism (defective
spleen function) are common causes of morbidity and mortality. The spleen is a secondary …

This report compiles and summarizes all published recommendations from CDC's Advisory
Committee on Immunization Practices (ACIP) for use of pneumococcal vaccines in adults …

A major diagnostic intervention in the consideration of many patients suspected to have
primary immunodeficiency diseases (PIDDs) is the application and interpretation of …

SUMMARY On February 24, 2010, a 13-valent pneumococcal polysaccharide-protein
conjugate vaccine (PCV13 [Prevnar 13, Wyeth Pharmaceuticals Inc., marketed by Pfizer …

To generate vaccine-mediated protection is a complex challenge. Currently available
vaccines have largely been developed empirically, with little or no understanding on how …

Background. A 23-valent unconjugated pneumococcal polysaccharide vaccine (23vP),
routinely administered at the age of 65, has limited effectiveness, and revaccination induces …

Common variable immune deficiency (CVID) is the most frequent symptomatic primary
immune deficiency in adults. The standard of care is intravenous immunoglobulin (IVIG) or …

Background The currently recommended single dose of the 23-valent pneumococcal free
polysaccharide vaccine (PPSV23) for adults 65 years of age and older does not provide …

Background Unlike free pneumococcal polysaccharide vaccines (PPSVs), pneumococcal
conjugate vaccines (PCVs) induce a T–cell–dependent immune response. The study …