Radiotherapy exerts immunostimulatory and immunosuppressive effects, both locally, within
the irradiated tumour microenvironment, and systemically, outside the radiation field …

Background Treatment-related lymphopenia (TRL) is common in patients with lung cancer,
particularly in those with radiotherapy. However, the influence of TRL on the efficacy of …

Patients with cancer can be immunocompromised because of their disease and/or due to
anticancer therapy. In this population, severe influenza virus infections are associated with …

Background and purpose The linear-quadratic (LQ) model has been pivotal for evaluating
the effects of radiation on cells, but it is primarily characterized by linear responses, which …

Purpose Lymphopenia is now generally recognized as a negative prognostic factor in
radiotherapy. Already at the beginning of the century we demonstrated that high-energy …

Ionizing radiation can have a wide range of impacts on tumor–immune interactions, which
are being studied with the greatest interest and at an accelerating pace by the medical …

Purpose The dose deposited outside of the treatment field during external photon beam
radiation therapy treatment, also known as out-of-field dose, is the subject of extensive study …

Background Radiation-induced lymphopenia (RIL) is closely related to the prognosis of
cervical cancer patients and may affect the efficacy of immune checkpoint inhibitors (ICIs) …

Immunotherapy has revolutionized the field of cancer treatment, changing the standard of
care to the use of immune checkpoint inhibitors. Radiotherapy can boost anti-tumour …

Background Immunotherapy provided significant survival benefits for recurrent and
metastatic patients with head and neck cancer. These improvements could not be …