Under physiological conditions, adenosine triphosphate (ATP) is present at low levels in the
extracellular milieu, being massively released by stressed or dying cells. Once outside the …

P2X7 receptors (Rs) constitute a subclass of ATP-sensitive ionotropic receptors (P2X1-
P2X7). P2X7Rs have many distinguishing features, mostly based on their long intracellular …

The proposed presence of P2X7 receptor (P2X7R) in neurons has been the source of some
contention. Initial studies suggested an absence of P2X7R mRNA in neurons, and the …

Recent investigations have revealed that the genetic deletion of P2X7 receptors (P2rx7)
results in an antidepressant phenotype in mice. However, the link between the deficiency of …

Parkinson's disease (PD) involves an initial loss of striatal dopaminergic terminals evolving
into a degeneration of dopaminergic neurons in the substantia nigra (SN), which can be …

Much progress has been made over the last few decades in the identification of new anti-
epileptic drugs (AEDs). However, 30% of epilepsy patients suffer poor seizure control. This …

The purpose of this study was to explore how genetic deletion and pharmacological
antagonism of the P2X7 receptor (P2rx7) alter mood-related behaviour, gene expression …

Abstract The P2X7 receptor (P2X7R), an ATP-gated cation channel, is expressed
predominantly in leukocytes. Activation of P2X7R has been implicated in the formation of a …

Potent actions of ATP in the central nervous system (CNS) were reported in the late 1940's,
but cloning and characterisation of receptors for purines and pyrimidines did not take place …

Migraine and major depression are debilitating disorders with high lifetime prevalence rates.
Interestingly these disorders are highly comorbid and show significant heritability …